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Vijay Kumar, Gampa
- Preparation and Evaluation of Solid Dispersion of Terbinafine Hydrochloride
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Authors
Affiliations
1 Seven Hills College of Pharmacy, Tirupati-517561, Andhra Pradesh, IN
2 Vikas Institute of Pharmaceutical Sciences, Andhra Pradesh, IN
3 Jawaharlal Nehru Technological University, Anantapur, Andhra Pradesh, IN
1 Seven Hills College of Pharmacy, Tirupati-517561, Andhra Pradesh, IN
2 Vikas Institute of Pharmaceutical Sciences, Andhra Pradesh, IN
3 Jawaharlal Nehru Technological University, Anantapur, Andhra Pradesh, IN
Source
Asian Journal of Pharmacy and Technology, Vol 3, No 1 (2013), Pagination: 9-15Abstract
Terbinafine hydrochloride is a synthetic antifungal drug. It is slightly soluble in water (3mg/ml) and having high permeability through stomach. This results in poor bioavailability after oral administration. Therefore solid dispersion of terbinafine HCl with polyethylene glycol-6000 (PEG 6000) and mannitol were prepared with a view to increase its water solubility. In this study solid dispersion of the drug were prepared by melting method and the drug was taken with carrier in the proportions of (1:1, 1:2 and 1:3). The rate of dissolution of terbinafine HCl was increased with the proportion of (1:3) (Drug: PEG 6000) when compared to the other formulations. In order to predict and correlate the release behavior of the drug from the polymer matrix the dissolution data were fitted in to a suitable model to describe the drug release behavior from polymeric system. The surface morphology of the prepared solid dispersion and drug alone were examined by SEM analysis. The SEM result shows that in the case of solid dispersion of terbinafine HCl, particles were in almost amorphous form, which indicates a reduction in particle size.Keywords
Antifungal, Bioavailability, Solid Dispersion, Polymer Matrix, SEM
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